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KMID : 0881720100250010030
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Journal of Food Hygiene and Safety
2010 Volume.25 No. 1 p.30 ~ p.35
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Elucidation and Analysis of Desmethylsibutramine in Food
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Kwon Chan-Hyeok
Yoon Tae-Hyung
Oh Jae-Ho
Lee Kwang-Ho
Choi Dong-Mi
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Abstract
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It has been elucidated desmethylsibutramine in food, that is an analogue of sibutramine used for anti-obesity drug. After separating and purifying in food samples, it was analyzed and identified by the instrument such as HPLC/PDA, HPLC/MS, HPLC/MS/MS and NMR. To analyze sibutamine and desmathylsibutramine in foods, they were analyzed and identified by HPLC/PDA after extracting in dichloromethane, filtering, concentration and diluting in methanol. The overall recoveries were ranged from 87% to 91% and the limit of quantitation was 2.5 μg/kg. As results, sibutramine and esmethylsibutramine was not detected in all the selected 54 food samples.
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KEYWORD
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desmethylsibutramine, anti-obesity drug, food, HPLC, NMR
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